Abstract: Objective: To investigate the compliance status of postoperative oral nutritional supplements (ONS) intake and its influencing factors in patients with colorectal cancer. Methods: A total of 183 patients with colorectal cancer were included. Univariate and multivariate analysis were applied to analysis the data. Results: Totally 44 patients (24.04%) had high compliance with postoperative ONS intake, 73 patients (39.89%) had good compliance with postoperative ONS intake, and 66 patients (36.07%) had poor compliance with ONS intake. Multivariate logistic regression analysis showed that the educational level, postoperative first meal time, and gastrointestinal tolerance are the independent influencing factors of postoperative ONS intake compliance in patients with colorectal cancer (P<0.05). Conclusion: In future clinical practice, it is necessary to strengthen patients' understanding of Enhanced Recovery After Surgery and health knowledge. It is also important to improve patients' awareness of the importance and precautions of postoperative ONS intake, and reduce gastrointestinal intolerance caused by the inappropriate frequency, temperature, and concentration of ONS intake.

Key words: colorectal cancer; Oral Nutritional Supplements; compliance; Enhanced Recovery After Surgery