Abstract: Objective: To summarize the relevant evidence on negative pressure wound therapy in patients with diabetic foot ulcers, aiming to establish standardized treatment plans and provide guidance and reference for healthcare professionals in clinical practice. Methods: All relevant content related to negative pressure wound therapy in patients with diabetic foot ulcers in relevant databases, guideline networks and websites of professional associations were systematically retrieved, including clinical decision-making, guidelines, expert consensus, evidence summaries, systematic reviews, and randomized controlled trials. The quality of the literature that met the inclusion criteria was evaluated, and the evidence was extracted and integrated. Results: A total of 12 articles were included, including one clinical decision-making, four guidelines, three expert consensus, one evidence summary, two systematic reviews, and one randomized controlled trial. A total of 20 pieces of evidence were formed in seven dimensions, including application purpose, application time, termination time, negative pressure parameters setting, negative pressure drainage material and replacement, skin protection and effect evaluation. Conclusion: Healthcare professionals should formulate personalized treatment plan according to the clinical evidence of negative pressure wound treatment in patients with diabetic foot ulcers, so as to improve their clinical outcomes.

Key words: diabetic foot ulcers; negative pressure wound therapy; evidence-based nursing; evidence summary