Abstract: Objective: To investigate the status and influencing factors of cancer-related fatigue in patients with Hematopoietic Stem Cell Transplantation. Methods: A survey of 200 patients after Hematopoietic Stem Cell Transplantation was performed using the General Information Questionnaire, Cancer Fatigue Scale, and Self-rating Anxiety and Depression Scale. Results: After Hematopoietic Stem Cell Transplantation, cancer-related fatigue score was 25.37±8.40, anxiety standard score was 44.71±7.86, anxiety incidence was 26.5%, depression severity index score was 0.50±0.09, and depression incidence was 41.0%. Multiple linear regression analysis showed that anxiety and depression were the main influencing factors of fatigue, which could explain 46.1% of the total variation. Conclusion: The fatigue level of patients after Hematopoietic Stem Cell Transplantation is high, medical staff can reduce the fatigue of patients after transplantation by screening and intervention of anxiety and depression.

Key words: Hematopoietic Stem Cell Transplantation; fatigue; mental flexibility; anxiety; depression