关键词: 冠状动脉旁路移植术；谵妄；危险因素；Meta分析

Abstract: Objective: To identify risk factors for delirium in patients with Coronary Artery Bypass Grafting (CABG). Methods: Computer retrieval of literature on the risk factors of delirium after CABG. The retrieval time limit is January 1, 2010 to May 31, 2021. After literature screenning, data extraction and quality evaluation, RevMan 5.3 software was used for Meta analysis. Results: A total of 19 articles were included. The statistically significant risk factors included age [OR=2.42, 95%CI (1.66-3.52)], cognitive impairment [OR=5.70, 95%CI (3.78-8.59)], depression [OR=3.76, 95%CI (2.75-5.13)], malnutrition [OR=2.56, 95%CI (1.60-4.11)], mechanical ventilation [OR=2.59, 95%CI (2.31-2.89)], cardiopulmonary bypass [OR=2.45, 95%CI (1.58-3.80)], observation time in ICU [OR=2.96, 95%CI (2.50-3.49)], cerebrovascular diseases [OR=2.48, 95%CI (1.76-3.49)], diabetes [OR=4.20, 95%CI (2.71-6.48)], anemia [OR=2.95, 95%CI (1.60-5.44)], complications [OR=3.08, 95%CI (2.21-4.31)] and increased creatinine [OR=2.28, 95%CI (1.56-3.34)]. Conclusion: There is heterogeneity in sample size, case selection and other aspects among different studies, which needs to be verified by more high-quality studies in the later stage to provide a basis for the development of clinical risk screening tools for postoperative delirium in CABG.

Key words: Coronary Artery Bypass Grafting; delirium; risk factors; Meta-analysis