关键词: 抗病毒治疗；获得性免疫缺陷综合征；血脂异常；体力活动；生活方式

Abstract: Objective: To analyze status of physical activity and ifluencing factors of dyslipidemia in HIV/AIDS patients receiving Highly Active Anti-Retroviral Therapy. Methods: A total of 306 HIV/AIDS patients admitted to Peking Union Medical College Hospital were surveyed. The general situation questionnaire and the International Physical Activity Questionnaire were used to investigate the current status. Meanwhile, serum cholesterol, triglyceride, HDL and LDL were tested. Results: There was a statistically significant difference in the distribution of physical activity between different genders (P=0.014). The incidence of dyslipidemia in this study was 58.50%, of which the incidence of hypercholesterolemia was 5.56%, the incidence of hypertriglyceridemia was 20.59%, and the incidence of low HDL-C was 35.29%. The incidence of dyslipidemia in men increased with age, and the incidence of dyslipidemia in female patients before and after menopause was higher. Multi-factor analysis showed that hypercholesterolemia was associated with sex (P=0.041), age (P=0.008), pre-treatment HIV viral load (P=0.004) and physical activity score (P=0.019); hypertriglyceridemia was only associated with BMI (P=0.002) and pre-treatment CD4 cell count (P=0.048); low HDL-C was associated with BMI (P=0.010), physical activity score (P=0.046), and pre-treatment CD4 cell count (P=0.043); dyslipidemia was generally associated with BMI (P=0.002). Conclusion: Blood lipid levels correlated with age, BMI, pre-treatment CD4 cell count and physical activity in HIV/AIDS patients receiving high-efficiency antiretroviral. Nursing staff should provide targeted health guidance and blood lipid monitoring to improve patient activity habits, thereby reducing the incidence of hyperlipidemia.

Key words: antiviral therapy; Acquired Immunodeficiency Syndrome; dyslipidemia; physical activity; lifestyle