Abstract: Objective: To explore the effects of prophylactic intervention based on the theory of "Timing It Right" in patients with rectal cancer on reducing the incidence and severity of postoperative Low Anterior Resection Syndrome (LARS). Methods: Totally 101 patients with low rectal cancer who were treated in the gastrointestinal surgery department of a tertiary grade A hospital from February 2020 to July 2021 were selected by convenience sampling method, and they were divided into 50 cases in the control group and 51 cases in the intervention group according to the order of admission time. The control group received routine care, and the intervention group received prophylactic intervention based on the "Timing It Right" on the basis of the intervention in the control group. The incidence, severity of LARS and quality of life were compared between the two groups at 1 month and 3 months after stoma reduction. Results: The LARS score and severity at 3 months after stoma reduction in the intervention group were significantly lower than that in the control group (P<0.05). The incidence (64.70%) was also significantly lower than that in the control group (88.00%) (P<0.05); and the quality of life in the intervention group was significantly higher than that in the control group at 1 month and 3 months after surgery (P<0.05). Conclusion: Prophylactic intervention based on the theory of "Timing It Right" can effectively reduce the incidence and severity of LARS in patients with low rectal cancer at 3 months after surgery, and improve patients' short-term quality of life after surgery.

Key words: Low Anterior Resection Syndrome; rectal cancer; Timing It Right; prophylactic intervention; nursing quality