Abstract: Objective: To investigate the association between job stress and the severity of coronary artery disease in young and middle-aged patients with Coronary Heart Disease (CHD). Methods: A total of 419 young and middle-aged patients who was performed coronary angiography in a hospital in Beijing from January to December 2020 were included. They were divided into CHD group and control group by convenient sampling method. Gensini score was used to evaluate the severity of coronary artery disease. The general information questionnaire and the Effort Reward Imbalance Questionnaire (ERIQ) were performed. Spearman correlation and logistic regression was used to analyze the association between job stress and severity of coronary artery disease. Results: There were statistically significant differences in effort, ERI and overcommitment among different coronary artery disease groups (P<0.05). Effort, ERI and overcommitment were positively correlated with Gensini score. Effort, ERI and overcommitment were the independent risk factors for the severity of coronary artery disease, and ERI had the greatest effect. Conclusion: Job stress is positively correlated with the severity of coronary artery disease. The effort, ERI and overcommitment can predict the severity of coronary artery disease.

Key words: young and middle-aged people; Coronary Heart Disease; job stress; severity of coronary artery disease; association