Abstract: Objective: To investigate the effect of AR somatosensory acupoint massage on symptom group in patients with breast cancer. Methods: Totally 180 patients with breast cancer after operation were divided into AR somatosensory Acupoint Massage (AR-AM) group, pressing Acupoint Massage (AM) group and Fake Acupuncture Massage (FAM) group with a ratio of 1:1:1. Patients accepted AR somatosensory acupoint massage, pressing acupoint massage and fake acupoint massage, five times a week. The brief Fatigue Inventory (BFI), The brief Pain Inventory (BPI), Pittsburgh Sleep Quality Index (PSQI) scale, Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used for scoring at the baseline, 4 weeks, 8 weeks (treatment end) and 12 weeks (end of the elution period). The Generalized Linear Mixed Models was used to evaluate fatigue, pain, sleep disorder, anxiety, and depression of the patients. Results: Among the 180 participants, 170 cases completed autonomous rehabilitation interventions, including 58 of AR-AM group, 56 of AM group, and 56 of FAM group. Compare the mean values of scores of fatigue, pain, sleep disorder, and depression between groups, the decline levels of AR-AM vs AM, AR-AM vs FAM and AM vs FAM have statistical difference after the 4th, 8th, and 12th weeks (P<0.001). Scores of fatigue, pain, sleep disorder and depression in the AR-AM group decreased the most, followed by the AM group, and no significantly changes in the FAM group. Anxiety was compared between groups. There was statistical difference in decline level of anxiety between AR-AM vs AM and AR-AM vs FAM at each time point (P<0.001). There was no statistical difference (P=0.164) on the 4th week, whereas there was statistical difference on the 8th week (P<0.05) and 12th week (P=0.053). The variables of fatigue, pain, sleep disorder, anxiety and depression were statistically significant between the two groups at 4th, 8th, and 12th weeks of intervention, and different interaction methods change significantly in accordance with different time period (P<0.001). Conclusion: AR somatosensory exercise acupoint massage can effectively relieve the fatigue, pain, sleep disorder, anxiety and depression symptoms of patients with breast cancer, and improve their quality of life.

Key words: Augmented Reality; somatosensory exercise; acupoint massage; breast cancer; symptom groups