Abstract: Objective: To summarize the evidence related to non-drug management of delirium and Subsyndromal Delirium in ICU, in order to promote knowledge translation, optimize delirium management and improve patient outcome. Methods: According to the evidence summary process issued by the Knowledge To Action project team, the evidence was retrieved, screened, evaluated, extracted and integrated. We searched and selected articles in both Chinese and English databases, websites of guidelines, related societies and clinical trial registration websites. After screening the articles, three researchers independently appraisal articles using validated tools. Qualitative evidence synthesis was formed to implicated the best practice of non-drug management of delirium and Subsyndromal Delirium in adult ICU patients. Results: Totally 47 articles were included for the evidence synthesis, 47 pieces of evidences including risk prediction, screening, prevention and treatment in delirium and Subsyndromal Delirium were summerized. Conclusion: The evidence for non-drug management of delirium and Subsyndromal Delirium is feasible, which could be translated to clinical practice to further verification.

Key words: delirium; Subsyndromal Delirium; Intensive Care Unit; non-drug management