Abstract: Objective: To evaluate the application effect of target management theory-based intervention strategy in preventing Central Line Associated Blood Stream Infection (CLABSI) among RICU patients. Methods: Patients with central vascular access devices from the RICU in a tertiary Grade A hospital during Jan 1, 2019 to Dec 31, 2020 were included in this study. The control group with routine nursing care were those during Jan 1, 2019 to Dec 31, 2019, and the intervention group with the target management theory-based intervention strategy on the basis of routine nursing care were during Jan 1, 2020 to Dec 31, 2020. The incidence of CLABSI, and the infection rate of PICC and CVC were compared between the two groups. Results: A total of 256 individuals were enrolled. For all the participants, 9 individuals were suffered from CLABSI, the incidence rate of CLABSI was 4.889‰, and the case infection rate was 4.02%. The incidence rate of CLABSI in the control group was 8.917‰, and 1.894‰ in the intervention group (P=0.043). Both the incidences of CLABSI in PICC catheterization and in CVC catheterization between the two groups were different respectively (P=0.028). Conclusion: The target management theory-based intervention strategy is benefit to decrease the incidence of CLABSI of patients in RICU obviously, to reduce the adverse prognosis, and it is worth to popularize in clinical nursing.

Key words: CLABSI; target management theory; central vascular access devices; intervention strategy; incidence