Abstract: Objective: To explore the effect of "Shaping Sunshine Mentality" counseling program on loneliness and happiness of hematology nurses. Methods: A total of 59 nurses from the hematology department of atertiary grade A hospital were recruited by convenient sampling method. The baseline survey was completed before the programme using the UCLA Loneliness Scale and the General Well-Being Schedule. The baseline survey was conducted again 1 week, 3 weeks, 2 months, 6 months and 12 months after the programme. Results: The results showed that compared with the teaching day, there was no significant improvement in the loneliness of nurses at 1 week, 3 weeks, 2 months and 6 months after the teaching (P>0.05), but the happiness increased significantly (P<0.05), and the loneliness decreased significantly (P<0.05) and the happiness increased significantly (P<0.05). Conclusion: "Shaping Sunshine Mentality" counseling program could significantly reduce the loneliness of nurses, improve their well-being, and has a certain long-term effect.

Key words: loneliness; happiness; nurse; psychological