Abstract: Objective: To explore the application effect of Immersive Virtual Reality technology in experiment teaching of intravenous injection. Methods: A randomized controlled trial was conducted and 125 students from the class of 2017 from a university were divided randomly into the experimental group (n=62) and the control group (n=63). Immersive Virtual Reality (the experimental group) and Non-immersive Virtual Reality (the control group) were compared under the trinity teaching mode of "real person training + model assistance + virtual training". Results: The post-test scores of the two groups were significantly higher than the pre-test scores after intervention, the performance of the experimental group is better than that of the control group (P<0.05). Students were generally satisfied with immersive teaching technology. The dimension scores of critical thinking and clinical reasoning and clinical learning in the experimental group was significantly higher than those in the control group (P<0.05). Conclusion: Immersive Virtual Reality technology improves students' mastery of teaching content, and students' satisfaction with virtual experience is high. Immersive Virtual Reality technology has a good application prospect in the field of nursing experiment teaching.

Key words: Immersive Virtual Reality; intravenous injection; experimental teaching