Abstract: Objective: To have a systematic review on the risk factors of Deep Venous Thrombosis (DVT) in brain hemorrhage patients. Methods: We systematically reviewed all articles related to the DVT risk factors in brain hemorrhage patients including Pubmed, Web of Science, the Cochrane Library, EMBASE, CNKI, Wanfang Data and CBM. Meta-analysis was conducted for quantitative analysis using RevMan 5.3 and descriptive analysis was adpoted as a supplement. Results: A total of 358 papers were retrieved, and 10 papers were included in the Meta analysis involving 19,447 patients with cerebral hemorrhage, of which 1,104 were diagnosed with DVT. Meta analysis showed that obesity [OR=9.45, 95% CI (1.81, 49.40), P=0.008], age [OR=3.84, 95%CI (2.57, 5.75), P<0.001], atrial fibrillation [OR=3.77, 95% CI (2.83, 5.02), P<0.001], paralysis [OR=6.73, 95% CI (1.69, 26.84), P=0.007], D-dimer [OR=607.42, 95%CI(488.19, 726.64), P<0.001]/[OR=8.24, 95%CI (6.36, 10.67), P<0.001], CRP values [OR=8.43, 95% CI (4.85, 14.65), P<0.001] and the average hospitalization time [OR=13.44, 95% CI (11.97, 14.90), P<0.001] were risk factors for DVT in patients with brain hemorrhage. The degree of neurological deficit assessed by National Institutes of Health Stroke Scale (NIHSS) was more applicable for western countries [OR=5.14, 95% CI (3.32, 6.97), P<0.001], but not for Asian countries [OR=9.06, 95% CI (0.58, 142.66, P=0.12]. Conclusion: Age, obesity, paralysis, atrial fibrillation, longer hospital stay, D-dimer and CRP were risk factors of DVT in patients with intracerebral hemorrhage, which could increase the incidence of DVT among those patients.

Key words: brain hemorrhage; Deep Venous Thrombosis; risk factors; Meta analysis; systematic review