Abstract: Objective: To investigate the prevalence of sarcopenia in patients with Chronic Obstructive Pulmonary Disease (COPD), and to explore its associated factors based on the health ecological model, so as to provide evidence for clinical interventions. Methods: The convenience sampling was employed to select inpatients with COPD admitted to two tertiary grade A hospitals in Huaihua between March and September 2025 as study subjects. Based on the health ecological model, a survey was conducted using the general information questionnaire, the Charlson Comorbidity Index (CCI), the COPD Assessment Test (CAT), the Short-Form Mini-Nutritional Assessment (MNA-SF), the Activities of Daily Living (ADL) Scale, the Brief 2-Way Social Support Scale, and the Patient Health Questionnaire-9. Additionally, muscle strength, appendicular skeletal muscle mass, and physical function were measured in the patients. A binary Logistic regression model was utilized to analyze the factors associated with sarcopenia in patients with COPD. Results: The prevalence of sarcopenia among patients with COPD was 23.2%. Age, gender, CAT score, CCI score, ADL ability, perceived social support, and depression were identified as independent associated factors (P<0.05). Conclusion: Sarcopenia exhibits a higher incidence in patients with COPD, with influencing factors encompassing personal characteristics, behavioural and psychological approaches, and interpersonal network dimensions within the health ecological model. It is suggested that clinical interventions should be developed from a multidimensional perspective to reduce the incidence of sarcopenia.

Key words: Chronic Obstructive Pulmonary Disease; sarcopenia; health ecology; influencing factor