Abstract: Objective: To develop the Entrustable Professional Activities (EPAs)-based evaluation indicators system for novice nurses in the hemodialysis department, providing a scientific basis for job training and competency assessment. Methods: An initial set of evaluation indicators was developed through literature review and group discussions. From July to August 2025, a Delphi survey was conducted among 22 experts to refine and finalize the EPAs evaluation indicators system for novice nurses in the hemodialysis department. Results: The response rates for both rounds of the Delphi survey were 100.0%. Kendall's W values were 0.133 and 0.093, respectively (P<0.05). The final evaluation system comprised 15 EPAs, covering key professional behaviors including vascular access assessment and care, routine and special blood purification procedures, and many other essential items. The expected entrustment levels at different stages, the required duration to achieve independent practice, and the corresponding core competencies for novice nurses were clearly defined. Conclusion: The EPAs-based evaluation indicators system developed in this study is scientifically sound and reliable, demonstrating comprehensive coverage and specialty relevance. It can serve as a reference for the training and assessment of novice nurses in the hemodialysis department.

Key words: hemodialysis; blood purification; nurse; Entrustable Professional Activities; Delphi technique