Abstract: Objective: To evaluate the effects of a home-based rehabilitation nursing integrating traditional Chinese and Western medicine based on mobile healthcare for stroke patients to provide reference for promoting the home-based rehabilitation for those patients. Methods: Using convenience sampling, stroke patients visiting the neurology department of a tertiary grade A hospital in Hangzhou were selected as the research subjects. According to the time of visit, 54 patients admitted from June to August 2024 were assigned to the control group and received conventional rehabilitation nursing, while 54 patients admitted from September to November 2024 were assigned to the experimental group and received a home-based rehabilitation nursing integrating traditional Chinese and Western medicine based on mobile healthcare aside from routine care. The self-management ability and quality of life of the two groups were compared, and the system usability evaluation of the "ZheLi Nursing" platform was collected from the experimental group. Results: After the intervention, the self-management and quality of life scores of the experimental group were significantly better than those of the control group (P<0.05). Additionally, 85.19% of the patients in the experimental group considered the system usability of the optimized "ZheLi Nursing" platform to be "good". Conclusion: The home-based rehabilitation nursing integrating traditional Chinese and Western medicine based on mobile healthcare can effectively improve the self-management ability and life quality of stroke patients. Moreover, it is feasible to use the "ZheLi Nursing" platform as a mobile healthcare carrier for intervention to provide a reference for clinical nursing practice.

Key words: mobile health; stroke; integration of traditional Chinese and Western medicine; home rehabilitation