关键词: 目的：将PICC相关性静脉血栓风险评估工具在临床应用，确立高危临界值，评价工具的灵敏度、特异度、阳性预测值、阴性预测值。方法：采用前瞻性研究设计，对143名肿瘤患者进行评估。于患者置管后24小时用PICC相关性静脉血栓风险评估工具进行评估，于置管后第7天、14天及21天，或患者有自觉症状时进行彩色多普勒超声检查是否有静脉血栓形成。结果：PICC相关性静脉血栓风险评估工具ROC曲线下面积为0.925（95%CI：0.861～0.988，P<0.001），最佳临界值为6.5分，对应的灵敏度为91.7%，特异度为85.0%，阳性预测值为67.4%，阴性预测值为96.9%。患者使用该评估工具评估得分在2～12分，高于6.5分的有49例，评分为高危的患者发生静脉血栓的风险是低危患者的21.102倍（RR=21.102，95%CI：6.814～ 65.346）。结论：PICC相关性静脉血栓风险评估工具对肿瘤PICC置管患者静脉血栓的发生风险有较好的预测价值。

Abstract: Objective: To evaluate the application effects of PICC related venous thrombosis risk assessment tool in cancer patients, to identify the critical value of high risk, and to evaluate the sensitivity, specificity, positive predictive value and negative predictive value of the tool. Methods: A prospective study was conducted, and 143 cancer patients were included. Patients were assessed with PICC related venous thrombosis risk assessment tool at the 24th hour after catheterization, and Color doppler ultrasound was performed on the 7th, 14th and 21st day after catheterization, or when patients felt related symptoms. Results: The area under ROC curve of the risk assessment tool was 0.925 (95% CI:0.861-0.988, P<0.001), the best critical valve of it was 6.5, the sensitivity was 91.7%, the specificity was 85.0%, the positive predictive value was 67.4%, and the negative predictive value was 96.9%. The score ranged from 2 to 12, and there were 49 patients with assessment scores above 6.5. The risk of thrombosis for patients with high-risk was 21.102 (RR=21.102, 95% CI: 6.814-65.346) times higher than that for patients with low-risk. Conclusion: PICC related venous thrombosis risk assessment tool has good value in predicting the risk of PICC related venous thrombosis in cancer patients.

Key words: PICC; PICC Related Venous Thrombosis; risk assessment