Abstract: Delirium is an acute, fluctuant change in mental status with inattention, disorganized thinking or an altered level of consciousness. Critically ill patients are in great risk of delirium because of the impact of psychological, environment, illness,and medications. Delirium could result in bad prognosis and clinical consequences of cognitive function in late stage. Thus, we should prevent delirium effectively and reduce its harmful effects. This paper reviewed the development of nonpharmacological interventions for the prevention of delirium in Intensive Care Unit both in China and abroad, in order to provide scientific and effective references for clinical practice.