Abstract: Objective: To investigate the status and influencing factors of Cancer Related-Fatigue (CRF) in children with Acute Lymphoblastic Leukemia (ALL). Methods: From December 2018 to September 2019, 102 cases of ALL children in two tertiary grade A hospitals in Zhejiang province were selected using convenience sampling. The general data questionnaire and PedsQLTM Multidimensional Fatigue Scale were used for investigation. Multiple linear regression was used to analyze the influencing factors of CRF. Results: The incidence of cancer-related fatigue in children with ALL was 98.04%, the mean score of CRF was (57.24±14.27). The scores of general fatigue, sleep fatigue, and cognitive fatigue were (51.88±21.01), (57.15±15.72), and (62.70±17.76). Multiple liner regression showed that age, clinical risk classification, related symptom clusters, activity patterns, and the length of time using electronic products were the influencing factors (P<0.05), which can explain 31.0% of the total variation. Conclusion: The prevalence of CRF among children with ALL was at high level. Clinical nursing staff should pay more attention to adolescents with ALL, high-risk group, and gastrointestinal symptom group; arrange the children's exercise reasonably, and control the length of time using electronic products to reduce their CRF level.

Key words: acute lymphoblastic leukemia; child; cancer-related fatigue; influencing factors