Abstract: Objective: Systematic analysis of the concepts, frameworks and influencing factors related to the scaling-up Best Practice Evidences (BPEs), in order to provide references for the future implementation of scientific evidence scaling-up. Methods: Based on the scoping review framework modified by Daudt, a systematic search was conducted to collect literature focusing on concepts, frameworks, and factors of BPEs scaling-up. Data were extracted by two researchers independently, and literature was analyzed by descriptive and thematic analysis. Results: A total of 28 articles were included. There is no accepted definition of scaling-up. Ten scaling-up frameworks, 5 scaling-up primary factors (including BPEs, user organizations, resource teams, environment, and scaling-up strategies), and 28 scaling-up secondary factors were identified. Conclusion: This study comprehensively integrated the relevant concepts, framework and influencing factors of BPEs scaling-up, which could provide practical information for evidence-based practice.

Key words: Best Practice Evidences; implementation science; scaling-up; concept; framework; factors; scoping review