Abstract: Objective: To understand the characteristics of Hospital-Associated Infection (HAI) with Multidrug-Resistant Organisms (MDRO) in Intensive Care Unit (ICU), and to provide evidence for prevention and control of HAI with MDRO. Methods: Prospective surveillance of HAIs with MDRO was performed from 2016 to 2018 in ICU. Descriptive analysis the incidence, strain composition and distribution of infection sites of HAIs with MDRO in ICU, comparing the composition of hospital infection sites and the distribution of different types of ICUs in different MDRO strains. Results: There were 197 cases of HAIs with MDRO in ICU from 2016 to 2018. The incidence of HAI was 2.73% and 5.40‰/1000-hospitalization day. CRAB was the most common MDRO in surgical, respiratory and cardiac surgery ICU. The most common MDRO strain in emergency ICU was CRE. ICU MDRO strain consisted of CRAB 59.39%, CRE 20.81%, CRPA 16.75%, MRSA 3.05%. The HAIs of MDRO were mainly in respiratory system, bloodstream, and wound. The HAIs of CRAB, CRE and CRPA mainly occurred in the respiratory system. The infection of MRSA was mainly caused by bloodstream infection. CRE was common in urinary tract infections. Conclusion: ICU is a high-risk department for MDRO. According to the characteristics of HAI, targeted prevention and control measures should be taken, especially the monitoring and prevention of key strains and sites.

Key words: Multidrug-Resistant Organisms; Hospital-Associated Infection; Intensive Care Unit