Abstract: Objective: To integrate the evidence for the prevention and management of neonatal PICC related thrombosis, so as to provide evidence-based evidence for clinical staff. Methods: The clinical decision-making website, guideline website, professional association website, evidence-based literature resource database, and original literature databases on the prevention and management of neonatal PICC related thrombosis were systematically searched from the establishment of the database to February 2023. The methodological quality of the literature that met the inclusion criteria was evaluated, and the evidence was extracted and summarized based on professional judgment and clinical context. Results: A total of 14 literature were included, including 2 clinical decisions, 6 guidelines, 4 systematic reviews, and 2 cohort studies. Totally of 31 pieces of evidence were summarized from 6 aspects: risk assessment, catheter placement, catheter maintenance, thrombosis diagnosis, thrombosis treatment, and extubation. Conclusion: The evidence summarizes the evidence for the prevention and management of neonatal PICC related thrombosis. Clinical staff can incorporate cultural backgrounds and clinical situations to select evidence, develop scientific thrombosis prevention and management plans, so as to enhance the quality of nursing care.

Key words: catheter-related thrombosis; PICC; neonate; summary of evidence