Abstract: Objective: To explore the project management mode of multi-center randomized controlled trial of nursing intervention and provide experience for clinical nursing research training and practice. Methods: According to the clinical trial management standard, this study elaborated the project management mode of multi-center nursing intervention randomized controlled trial from the four stages of project evaluation, planning, implementation and evaluation. Patient recruitment rate, retention rate, nurse participation retention rate, and training compliance were used to evaluate the feasibility of the project management mode and the effect of scientific research training in the randomized controlled trial of multi-center nursing intervention. Results: The patient recruitment rate was 73.3%, the retention rate of patients in the intervention group was 96.4%, the retention rate of nurse participation was 89.3%, the training compliance was 78.6%. Conclusion: The project management mode of multi-center randomized controlled trial about the family intervention for breast cancer patients is feasible, which provides an empirical reference for clinical nurses and nursing graduate students to design and implement multi-center randomized controlled trial. Meanwhile, the practice-oriented research training can stimulate nurses' interest in research and improve their research ability.

Key words: nursing intervention; multi-center randomized controlled trial; science research management; team recruitment; quality evaluation