Abstract: Objective: To explore the effect of COX's Interaction Model of Client Health Behavior on smoking cessation for tobacco dependent patients. Methods: A convenience sample of 77 tobacco-dependent patients from a smoking cessation clinic in a tertiary first-class hospital in Wuhan was divided into groups according to the time of visit. Among them, 38 patients from November 2018 to January 2019 were the control group, and routine smoking cessation interventions were used. Another group of 39 patients from February to April 2019 was the observation group and was implemented smoking cessation interventions based on the COX's Interaction Model of Client Health Behavior. Results: There were statistically significant differences in the time effect, grouping effect, and interaction effect of tobacco dependence scores between the two groups of patients (P<0.05). After the intervention, the scores of tobacco dependence in the observation group were lower than those in the control group at one month and six months after the intervention, and the difference was statistically significant (P<0.05); in the two groups of smoking craving scores, the main effect of patient time was significant (P<0.001) , while the main effect of grouping was not significant (P>0.05). There was a statistically significant difference in smoking craving scores between the two groups of patients one month after the intervention (P<0.05). There was no significant difference in smoking craving scores between the two groups of patients six months after the intervention (P>0.05). The smoking cessation rate of 1 month and 6 months after intervention in the observation group was higher than that in the control group (P<0.05), and the observation group had a high recognition of smoking cessation intervention based on the COX's Interaction Model of Client Health Behavior. Conclusion: The smoking cessation interventions based on the COX's Interaction Model of Client Health Behavior can help reduce the tobacco dependence and further increase the smoking cessation rate. Patients have a high degree of acceptance on the interventions. However, there is no improvement in their smoking cravings.

Key words: COX's Interaction Model of Client Health Behavior; tobacco dependence; craving for smoking; smoking cessation clinic; smoking cessation intervention