Abstract: Objective: To evaluate the effectiveness of the mobile medical care model based on Online-to-Offline in patients with initial basal insulin treatment. Methods: A mobile health management system based on Online-to-Offline with mobile terminals for the doctors, nurses, and patients was applied in the program. For all the recruited T2DM patients, the baseline information was collected and a first-day health education was provided. In the following 12 weeks, basal insulin doses and fasting plasma glucose (FPG) were collected online by text messages or phone call, and standardized health education and glycemic control guidance both online and offline were provided to patients. Results: Totally 1 051 patients were enrolled and 852 patients completed the 12 weeks follow-up. In total, 84.3% patients reached the FPG control target in the follow-up. The result by generalized estimation equation model suggested that the patients' FPG value was decreased after 1, 2, 4, 8 and 12 weeks, The FPG control rate of patients at the baseline, in week 1, 2, 4 and 8 was 0.009, 0.098, 0.172, 0.260, 0.286 times of that in 12 week, respectively, The FPG control rate of the patients with incomplete self-monitoring blood glucose data was 0.658 times of that of the complete group. The FPG control rate of the those who had never participated in the education program was 0.770 times of that of others (P<0.05). Conclusion: The mobile medical care model based on Online-to-Offline is an effective way to improve the blood glucose management level of patients treated with basal insulin.

Key words: diabetes mellitus; basal insulin; generalized estimation equation; glycemic control; mobile health