Abstract: Objective: To translate and revise the Prognosis and Treatment Perception Questionnaire (PTPQ), and test its reliability and validity. Methods: The English version of PTPQ was translated, back-translated, cultural modified and revised based on Brislin translation model. The Chinese version of PTPQ was then applied to 198 patients with advanced cancer to evaluate its reliability and validity. Results: The Chinese version of the PTPQ consisted of two parts, with a total of 17 items. Four common factors were extracted by exploratory factor analysis, and the cumulative variance contribution rate was 82.513%. The content validity index of each item (I-CVI) in the questionnaire was 0.80-1.00, and the average content validity index (S-CVI/Ave) was 0.91. The overall Cronbach's α coefficient of the questionnaire was 0.845, the Cronbach's α of each factor was 0.688-0.956, and the Guttman's half-fold reliability coefficient was 0.867. Conclusion: The Chinese version of PTPQ has good reliability and validity, and it can effectively evaluate the prognosis and treatment cognition of advanced cancer patients for clinical medical staff in China.

Key words: Prognosis and Treatment Perception Questionnaire; advanced cancer patients; reliability; validity