Abstract: Objective: To analyze the status quo of disease self-management and related factors in People Living With HIV (PLWH), as well as the relationship between disease self-management and quality of life, and to provide reference for improving the level of disease self-management in this population. Methods: From September to December 2018, we consecutively recruited 555 PLWHs from an HIV clinic in Hunan province. General information questionnaire, and HIV related clinical data questionnaire, self-management scale for PLWH and WHO QOL-HIV BRIEF scale were used to collect data. Bivariate analysis was used to explore the related factors, and multivariable generalized linear regression was conducted to confirm the related factors to self-management. Results: The total score of self-management was 170.50±22.98, with a score rate of 69.6%, which was at the moderate. The level of self-management of diseases was positively related to quality of life. Multi-factor analysis showed that sexual orientation, taking antiretroviral therapy, having comorbidities, and perceived support or stigma from people who know their HIV status were significantly associated with self-management in people living with HIV. Conclusion: The self-management of PLWHs is related to the quality of life and needs to be promoted. Interventions needs to incorporate more complex management knowledge and techniques should be included to help PLWH coping with comorbidities, antiretroviral therapy, and infection status disclosure, etc.

Key words: disease self-management; Acquired Immunodeficiency Syndrome; quality of life