Abstract: Objective: To establish a Standard Operating Procedure (SOP) for nursing care during intraventricular chemotherapy via an Ommaya reservoir, providing a basis for standardized nursing practice. Methods: A preliminary nursing SOP was drafted through literature review and clinical observation. It was refined after two rounds of Delphi expert consultations among 14 experts from May to June 2025. Results: The valid response rates for the two rounds of consultations were 100.0% and 85.7%, with expert authority coefficients of 0.857 and 0.854. In the second round, the variation coefficients for importance ratings of primary, secondary, and tertiary items ranged from 0 to 0.077, 0 to 0.101, and 0 to 0.101, respectively; Kendall's coefficients of concordance were 0.228, 0.265, and 0.217 (all P<0.001). The final SOP included 5 primary, 22 secondary, and 39 tertiary items. Conclusion: This SOP is scientific, reliable, and comprehensive, systematically standardizing the chemotherapy process and ensuring professional care.

Key words: leptomeningeal metastasis; Ommaya reservoir; intraventricular chemotherapy; nursing; Standard Operating Procedure; Delphi method