Abstract: Objective: To retrieve, evaluate and summarize the evidence for oral hygiene promotion strategies during chemoradiotherapy in patients with head and neck cancer, and to provide evidence for clinical practice. Methods: Using the "5S" evidence hierarchy pyramid, a systematic search was conducted in both domestic and international professional websites and databases for evidence related to strategies promoting oral hygiene in patients with head and neck cancer during radiotherapy and/or chemotherapy. The search covered literature from database inception to June 30, 2025. After quality appraisal and data extraction, the evidence was synthesized. Results: Seventeen articles were enrolled, consisting of ?2 clinical decisions, 3 guidelines, 4 expert consensus, 4 evidence summaries, and 4 systematic reviews. Sixteen pieces of evidence were summarized covering five aspects: forming multidisciplinary oral care team, teeth and gum cleaning, mouthwash selection and use, oral hygiene education and follow-up management. Conclusion: The synthesized evidence on oral hygiene promotion strategies for patients with head and neck cancer during chemoradiotherapy is scientific and practical, offering an evidence-based reference for personalized oral hygiene guidance by healthcare professionals.

Key words: head and neck cancer; radiotherapy; oral hygiene; oral care; evidence summary; evidence-based nursing