Abstract: Objective: To evaluate the effectiveness of mobile health (mHealth)-based remote interventions in improving fatigue in patients with Multiple Sclerosis (MS) and to provide evidence for fatigue management in this population. Methods: We systematically searched Chinese and English databases from inception to August 29, 2025. Two researchers independently screened studies and assessed their quality. Meta-analysis were performed using RevMan 5.4 and Stata 18 software. Results: Ten studies involving 761 MS patients (371 in intervention groups, 390 in control groups) were included. The Meta-analysis demonstrated that mHealth-based remote interventions yielded significantly greater immediate improvements in fatigue severity [SMD=-1.02, 95%CI(-1.92, -0.13)] and fatigue impact [SMD=-0.88, 95% CI (-1.62, -0.15)] compared to controls. Further subgroup analyses revealed that remote interventions with a duration of ≤12 weeks exerted a more pronounced immediate improvement effect on both fatigue severity [SMD=-0.59, 95%CI (-1.12, -0.06)] and fatigue impact [SMD= -0.77, 95%CI (-1.34, -0.20)] compared with the control group; Remote interventions delivered via group video conferencing demonstrated a superior immediate improvement effect on fatigue impact compared with the control group [SMD= -0.53, 95% CI (-0.93, -0.13)]. However, no statistically significant long-term effects were observed for either fatigue severity [MD=-0.21, 95% CI (-0.46, 0.05)] or fatigue impact [MD=-6.17, 95% CI (-12.48, 0.14)]. Conclusion: mHealth-based remote interventions can provide immediate relief for MS-related fatigue severity and impact. Future studies should incorporate longer follow-up assessments to enhance understanding of long-term fatigue management in MS patients.

Key words: multiple sclerosis; fatigue; remote intervention; Meta-analysis