Abstract: Objective: To explore the experience of medication safety management participation among hospitalized older adults with Cardiometabolic Multimorbidity, in order to inform the development of a patient-centered medication safety management model. Methods: A purposive sampling approach was employed to conduct a descriptive qualitative study. Semi-structured face-to-face in-depth interviews were carried out from June to October 2024 with 16 hospitalized older adults with Cardiometabolic Multimorbidity in a tertiary grade A hospital in Jiangsu province. The collected data were analyzed using directed content analysis based on the Capability, Opportunity, Motivation-Behavior model. Results: A total of 2 themes and 9 sub-themes were identified, including facilitating experiences (efficient medication self-management skills, accurate medication beliefs, and diversified social support) and hindering experiences (physical function decline, lack of medication knowledge, negative medication-related emotions, lack of sense of responsibility in health management, barriers in hospital systems and operational models, and lack of authoritative information). Conclusion: The involvement of hospitalized older adults with Cardiometabolic Multimorbidity in medication safety management presents a complex characteristic of coexisting facilitating and hindering experiences. It is essential to strengthen the facilitating experiences while systematically addressing the hindering experiences, so as to enhance patient participation and ensure medication safety.

Key words: Cardiometabolic Multimorbidity; the aged; patient participation; medication safety; qualitative study