Abstract: Objective: To retrieve, evaluate, and summarize relevant evidence on the prevention and management of infiltration and extravasation injuries in neonates to guide clinical practice. Methods: We searched UpToDate, BMJ Best Practice, CNKI and other Chinese and English database or websites to collect relevant guidelines, clinical decisions, evidence summaries, systematic reviews and expert consensuses published from January 1, 2013 to March 31, 2024. Four researchers who had received systematic evidence-based knowledge training independently evaluated the quality of the literature and extracted evidence. Results: A total of 10 articles were included, including 4 guidelines, 3 expert consensuses, and 3 systematic reviews. A total of 24 pieces of evidence were collected, mainly involving 4 aspects of skin assessment, venous catheter assessment, classification and treatment of infiltration and extravasation, quality control. Conclusion: This study summarizes the evidence for the prevention and management of infiltration and extravasation injuries in neonates, providing a basis for preventing extravasation in clinical intravenous infusion. It suggests that clinical nursing measures should be formulated based on evidence, combined with the actual situation of departments and neonates, to reduce the occurrence of infiltration and extravasation in neonatal peripheral intravenous infusion and improve nursing quality.

Key words: neonate; extravasation; evidence-based nursing; evidence summary