Abstract: Objective: To explore the effects of multidisciplinary collaboration combined with the critical value management mode on the prevention and control of Multi-Drug Resistant Organisms (MDROs) infection in the liver transplantation ward. Methods: Patients in the liver transplantation ward of a hospital from July 2017 to July 2020 were selected as the research subjects. MDT combined with the critical value management mode was applied to the prevention and control of MDROs infection from July 2018, and continuous quality improvement was carried out one year later. Indicators including the infection rate of MDROs, the implementation rate of isolation measures and the omission rate of report of inpatients were compared before and after the implementation, and after the application of continuous quality improvement. Results: The infection rate of MDROs before the implementation, after the implementation and after continuous quality improvement was 2.88%, 1.84% and 1.39%, respectively, showing a decreasing trend with statistically significant differences (P<0.05). The overall implementation rate of MDROs prevention and control measures increased (P<0.001), and indicators like the compliance and accuracy rate of hand hygiene, the compliance of wearing isolation clothes, the compliance of reporting outside examination information and so on were significantly improved, with statistical significance (P<0.001). The omission rate of MDROs infection was 28.57%, 16.00% and 4.76% before the implementation, after the implementation and after continuous quality improvement, respectively, with statistically significant differences (P<0.05). Conclusion: The establishment of a multidisciplinary infection management team, the inclusion of the critical value management mode, and the strengthening of the two-level supervision between hospital and department can significantly improve the implementation rate of multi-drug resistant bacteria isolation measures in the liver transplantation ward to effectively reduce the infection rate and the omission rate of MDROs cases.

Key words: Multi-Disciplinary Team; liver transplantation ward; Multi-drug Resistant Organisms; infection prevention and control; continuous quality improvement