Abstract: Objective: To explore the construction and development of specialty nursing under Multidisciplinary Treatment(MDT) for head and neck cancer. Methods: After establishing multidisciplinary medical team, the team members implemented multidisciplinary discussion process, hierarchical training of professional nurses, and problem based case discussion. And then they developed patient-centered case management model through tracking clinical nursing pathway. Results: Satisfaction among the patients, doctors and nurses improved obviously. Professional knowledge, familiar level of patients' condition and team building status in nurse team improved significantly as compared with before (P<0.01). Conclusion: The construction of specialty nursing under the MDT mode could significantly improve the nurses' professional abilities to provide high quality care for patients.