Abstract: Objective: To apply the evidence of nursing care of gastrointestinal symptom clusters in colorectal cancer patients with chemoradiotherapy and evaluate the effects, so as to provide reference for symptom management. Methods: Based on Knowledge to Action Framework (KAT), the evidence-based nursing practice of gastrointestinal symptom clusters in colorectal cancer patients with chemoradiotherapy was carried out from December 2021 to November 2022, which included three steps: knowledge output, knowledge introduction and knowledge application. The knowledge mastery level of medical staff and implementation rate on the review indicators, and the incidence of gastrointestinal symptoms were compared before and after the application of evidence. Results: After the evidence-based nursing practice, the knowledge scores of medical staff increased from 52.27±14.73 to 77.00±7.44, and the implementation rate of 14 review indicators increased from 0-91.11% to 71.43%-100.00%, and the incidence of vomiting and diarrhea in the intervention group was lower than that in the control group (P<0.05). Conclusion: KTA provides guidance for evidence-based nursing practice, which is benefit to improve the relative knowledge and behavior of medical staff and decrease the incidence of gastrointestinal symptoms in colorectal cancer patients.

Key words: digestive system neoplasms; chemoradiotherapy; signs and symptoms, digestive; evidence-based nursing