Abstract: Objective: To explore the application effects of genetic risk assessment and management model of gastric cancer led by oncology nurses. Methods: From July 2020 to June 2022, the model was led by oncology specialist nurses, combined with gastric cancer medical experts. Genetic risk assessment, genetic testing guidance, gastric cancer risk management and follow-up care were provided. Results: A total of 842 people were screened and 74 people (8.77%) with hereditary gastric cancer risk were enrolled. Totally 15 people (1.78%) underwent genetic testing, and 3 people (0.36%) had cancer susceptibility genes mutation. Gastric cancer risk knowledge scores at the one-month follow-up stage were higher than those at the cancer risk assessment stage and the cancer risk management stage (P<0.05). Hospital Anxiety and Depression Scale scores were all in the normal range (P>0.05). The compliance rate of gastric cancer risk management at the six-month follow-up stage was higher than that at the one-month follow-up stage. The overall satisfaction of patients was 98.64%. Conclusion: The genetic risk assessment and management model of gastric cancer led by oncology nurses is beneficial to the improvement of gastric cancer risk knowledge level and the compliance rate of gastric cancer risk management plan without anxiety, depression and other negative psychological effects, which is worthy of clinical promotion.

Key words: Advanced Practice Nurse; gastric cancer; genetic risk assessment; risk management; anxiety; depression