Abstract: Objective: To explore the application effect of Quality Control Circle (QCC) management tool in reducing nonplanning re-inspection rate of the blood coagulation function test in ICU. Methods: Under the principle of PDCA circulation, we set up QCC group, established the activity theme as "reducing non-planning re-inspection rate of the blood coagulation function test in ICU ", invested the present situation, set goals, analyzed the reason and selected countermeasures. Results: Non-planning re-inspection rate of the blood coagulation function test in ICU decreased from 8.93% to 2.24% (P<0.05) after carrying out QCC activity, the difference was statistically significant. Conclusion: The management of the blood coagulation samples with QCC activity can not only effectively reduce non-planning re-inspection rate of the blood coagulation function test in ICU, but also reduce the unnecessary medical cost and the waste of the patient's blood.