关键词: 新生儿；大疱性表皮松解症；皮肤管理；创面管理；循证护理学

Abstract: Objective: To retrieve, evaluate, and summarize the evidence on skin and wound management in neonates with Epidermolysis Bullosa (EB) to provide a reference for clinical practice. Methods: According to the "6S" evidence resource pyramid model, clinical decisions, best practices, guidelines, evidence summaries, expert consensus, expert opinions, systematic reviews, and randomized controlled trials on skin and wound management of neonates with EB were systematically searched in relevant websites as well as Chinese and English databases from January 1, 2014 to September 30, 2024. The quality of the included papers was evaluated and the evidence was extracted and summarized. Results: A total of 9 articles were finally included, among which there were 2 clinical decisions, 1 guideline, 5 expert consensus and 1 best practice. Finally 31 pieces of evidence for skin and wound management in neonates with EB were formed from 3 aspects, including skin management, wound management, and pain management. Conclusion: The evidence of skin and wound management in neonates with EB can provide an evidence-based basis for the clinical practice of medical staff.

Key words: neonates; Epidermolysis Bullosa; skin management; wound management; evidence-based nursing