Abstract: Objective: To develop a process quality control toolkit for the prevention of central venous Catheter-Related Bloodstream Infections in blood purification, in order to provide a reference for reducing infection incidence and improving specialized nursing quality. Methods: The initial draft of the Process Quality Control Toolkit for Preventing Central Venous Catheter-Related Bloodstream Infections in Blood Purification was formulated based on a literature review. Two rounds of Delphi expert consultations were conducted among 30 experts in September and November 2025, respectively. The toolkit was revised according to the results of expert consultations. A pilot clinical implementation was carried out in 44 hospitals in Guangdong province from January to March 2026. The toolkit was further refined with clinical feedback to form the final version. Results: The questionnaire response rate of both rounds of consultation reached 100%. The expert authority coefficients were 0.927 and 0.933, and Kendall's coefficients of concordance were 0.274 and 0.361, respectively (all P<0.001). A total of 11 pieces of feedback were collected during the pilot clinical implementation. The final toolkit covered 8 dimensions, such as organization and management, core prevention and control principles for catheter-related operations, and pre-procedure assessment for catheter-related operations, involving 55 nursing measures in total. Conclusion: The developed toolkit has favorable scientificity and reliability with comprehensive contents, which can serve as a practical tool for standardized management of central venous catheters for blood purification.

Key words: blood purification; central venous catheter; Catheter-Related Bloodstream Infection; quality control; toolkit; Delphi method