Abstract: Objective: To develop an evidence-based clinical protocol for non-pharmacological interventions for children with Functional Abdominal Pain (FAP) and evaluate its clinical application effects, thereby providing a basis for nursing care. Methods: Evidence for non-pharmacological interventions for FAP was identified through literature screening, evaluation, and synthesis. Evidence-based practice was implemented in the gastroenterology department of a tertiary grade A hospital in Guangdong province from June 2024 to January 2025. Based on the evidence summary, audit criteria were developed. The Ottawa Model was used to assess potential barriers and formulate corresponding strategies. Comparisons were made before and after the practice regarding nurses' implementation rates, the knowledge levels of medical staff and family members, and the improvement in children's pain. Results: After the application of evidence, nurses' implementation rates for various audit criteria were higher than those before the practice. The family members' knowledge score for FAP increased from 59.67±8.31 to 81.18±8.06, the medical staff's knowledge score for FAP increased from 69.83±5.92 to 88.28±6.43. The children's abdominal pain intensity decreased from 3.82±1.05 to 2.13±0.87, and the frequency of episodes decreased from 4.50±1.20 to 2.80±0.90 times per day. These differences were statistically significant (all P<0.05). Conclusion: The multidisciplinary collaborative non-pharmacological intervention model can effectively improve nursing quality on children with FAP, enhance family members' capabilities, and alleviate children's symptoms, demonstrating good value for clinical application.

Key words: Functional Abdominal Pain; non-pharmacological intervention; evidence-based nursing practice