Abstract: Objective: To translate and test the reliability and validity of the Hazardous Drug Handling Questionnaire (HDHQ), in order to provide a scientific and reliable measurement tool for the assessment of nurses' occupational protection against hazardous drugs in China. Methods: Following Brislin's translation model, HDHQ was translated, back-translated, culturally adapted and pre-investigated to form its Chinese version. From March to April 2024, a total of 406 nurses in Beijing were selected by convenience sampling method to conduct a questionnaire survey to test the reliability and validity of the questionnaire. Results: The Cronbach's α coefficient of the Chinese version of HDHQ was 0.892, and the test-retest reliability test showed that the ICC was 0.782. Besides, the Cronbach's α coefficient of the influencing factors was 0.742-0.971 with the ICC being 0.536-0.823. The I-CVI and S-CVI of Chinese version of HDHQ was 0.80-1.00 and 0.90-1.00, respectively. Nurses who had received protection training scored higher in terms of using hazardous drugs safety protection measures than those who had not received training, and the difference was statistically significant (P<0.05). Nurses' score of hazardous drug safety measures was positively correlated with the total score of Competency Inventory for Registered Nurses (r=0.334, P<0.05), showing good model fit. Conclusion: The Chinese version of HDHQ has good reliability and validity thus can be used as an assessment tool for the current situation of occupational protection against hazardous drugs in nursing staff.

Key words: hazardous drugs, handle, questionnaire, reliability, validity