Abstract: Objective: To explore the application effect of symptom management dynamic model in the whole-course management of lymphoma patients undergoing chemotherapy. Methods: Patients with preliminary hospitalized in the lymphoma ward of a tertiary grade A tumor hospital from May 2020 to February 2021, were assigned into the intervention group (106 cases) and the control group (100 cases) according to the order of admission. The intervention group received the whole-course management based on the symptom management dynamic model. The control group was given routine nursing combined with symptom diary, and the total intervention time was 6 cycles, respectively before the first cycle of chemotherapy and after the end of the sixth cycle of chemotherapy. The differences in chemotherapy complications, total burden of symptoms, quality of life and delayed chemotherapy between the two groups were compared. Results: Chemotherapy complications: After 6 cycles of intervention, the incidence of delayed chemotherapy in the intervention group was lower than that in the control group (P<0.05), the incidence of bone marrow suppression in the intervention group was lower than that in the control group (P<0.05); Quality of life: Repeated measures analysis of variance showed that the emotional function scores of the two groups existed time and interaction effects, nausea and vomiting, loss of appetite scores existed time, inter-group and interaction effects, fatigue and financial burden scores existed time and inter-group effects, constipation and diarrhea scores only existed time effect (all P<0.05). Conclusion: Symptom management dynamic model intervention can reduce the incidence of delayed chemotherapy and myelosuppression in lymphoma patients, improve their quality of life, and provide reference for the implementation of the whole-course management of lymphoma patients.

Key words: lymphoma; symptom model; whole-process management; the quality of life