Abstract: Objective: To investigate the status and influencing factors of self-regulatory fatigue in patients with Systemic Lupus Erythematosus, and further explore the impact path of factors, providing a reference for developing targeted intervention strategies. Methods: By using the convenience sampling method, 215 patients with Systemic Lupus Erythematosus admitted to the Department of Rheumatology and Immunology of four tertiary grade A hospitals in Guangdong province from June to October 2024 were selected as research subjects. The General Information Questionnaires, Self-Regulatory Fatigue Scale, Fear of Progression Questionnaire-Short Form, Health Literacy Scale for Patients with Chronic Disease, Medical Coping Modes Questionnaire and Morisky Medication Adherence Scale-8 were used for investigation. The stepwise multivariate linear regression analysis was used to analyze the influencing factors of self-regulatory fatigue in patients, and based on the common-sense model of self-regulation, the maximum likelihood method was used for path analysis. Results: The score of Self-Regulatory Fatigue Scale of patients with Systemic Lupus Erythematosus was 43.16 ± 8.74. The stepwise multivariate linear regression analysis indicated that fear of progression, health literacy, yielding coping and medication adherence were the influencing factors of self-regulatory fatigue in patients with Systemic Lupus Erythematosus (P<0.05). The path analysis showed that fear of progression, yielding coping and medication adherence directly influenced the degree of self-regulatory fatigue, and fear of progression influenced the degree of self-regulatory fatigue by the yielding coping, the health literacy influenced the degree of self-regulatory fatigue by the mediating of yielding coping and medication adherence. Conclusion: Patients with Systemic Lupus Erythematosus have a high degree of self-regulatory fatigue, and it is urgent to develop intervention strategies based on patient's fear of progression, health literacy, coping mode, and medication adherence to reduce their degree of self-regulatory fatigue and improve their ability of self-management.

Key words: Systemic Lupus Erythematosus; self-regulatory fatigue; fear of progression; health literacy; coping mode; medication compliance; path analysis