Abstract: Objective: To evaluate the impact of body bathing with chlorhexidine solution on preventing catheter associated urinary tract infections in ICU. Methods: Electronic searches of databases were performed to identify relevant randomized controlled trials (RCTs) and clinical control studies (CCTs). The databases used were Cochrane Library,PubMed, Medline/Ovid, EMbase, CBM, VIP, CNKI, and Wan Fang Data. Two reviewers independently screened potentially eligible articles, extracted data and assessed risk of bias. RevMan 5.3 software was used to perform Metaanalysis and sub-group analysis. Results:8 published studies were recruited for systematic review, which contained 2 RCTs and 6 CCTs. The results of Meta-analysis showed that, compared with non-medicated soap group, body bathing with chlorhexidine had significantly decreased the incidences of catheter associated urinary tract infection [RR=0.76, 95% CI(0.60~0.95), P=0.02]. Conclusions: Total body bathing with chlorhexidine is associated with decreased catheter associated urinary tract infection rate in ICU.