Abstract: Objectives: To investigate the current state of nurse's self-efficacy and job involvement, to explore the relationship between them, and to provide reference for improving management efficiency among head nurses. Methods: Totally 368 nurses in two tertiary Grade A hospitals in Sichuan province were recruited randomly and investigated by questionnaires. Results: The mean score of nurses' self-efficacy is (83.51±11.62). The nurses showed a high level of job involvement (57.54±9.78). The nurses' self-efficacy has positively predictive impact on nurses' job involvement. Conclusion: Nursing managers should take effective measures to improve nurse's self-efficacy, to maximize nurses' job involvement, to reduce job burnout, and to enhance the core competence of the hospital.