Abstract: Objective: To explore the effect of comprehensive intervention strategies on physical restraint minimization action in SICU. Methods: We developed and implemented comprehensive intervention strategies for physical restraint minimization action in SICU. We assessed the effect of the intervention by the scores of Questionnaire of ICU nurse's knowledge,attitude and practice toward physical restraint, the prevalence of using physical restrict and unplanned extubation rate in SICU before and after nursing intervention. Results: After nursing intervention, the mean scores of the questionnaire was higher than that before the intervention (P<0.05). The prevalence of using physical restrict was significantly decreased (P<0.05), while the unplanned extubation rate did not increase. Conclusion: Comprehensive intervention strategies could enhance SICU staff nurses'knowledge, attitudes and practices toward physical restrict, reduce prevalence of using physical restraint, decrease rates of unplanned extubation,, and achieve the goal of physical restraint minimization action.