Abstract: Objective: To construct a Clinical Decision Support System for assessing and preventing Pressure Injury (PI) in hospitalized children and evaluate its effectiveness, assisting nurses with clinical decision-making, reducing PI incidence. Methods: We designed human-computer interaction rules, and developed a Clinical Decision Support System for PI assessment and prevention based on evidence. This system enables dynamic risk assessment, real-time warnings, intervention recommendations, and continuous monitoring and analysis. The system was formally applied in a tertiary grade A comprehensive pediatric hospital in Beijing in March 2024. We compared the timeliness rate of 2-hour assessments, the accuracy rate of assessment accuracy, and PI incidence of hospitalized children before and after the application of the system, and the satisfaction of nurses with the system was assessed. Results: Following system implementation, the timeliness rate of the 2-hour assessments was increased from 82.5% to 91.2%, the accuracy rate of PI assessment was increased from 89.7% to 93.8%, and the PI incidence was decreased from 3.60% to 0.91%, the differences were statistically significant (P<0.05). The nurses expressed high satisfaction with the system, with an overall satisfaction score of 93.79±17.71. Conclusion: The construction and application of the system provide a scientific basis for nursing make decision-making, aid in the prevention and management of PI, improve nursing quality and nurse work efficiency.

Key words: Clinical Decision Support System; pediatric; Pressure Injury; information system; nursing