Abstract: Objective: To examine the effects of clearance breathing on pulmonary function and treatment compliance in patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease undergoing first non-invasive ventilation. Methods: A total of 99 patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease undergoing the non-invasive ventilation for the first time in the Intensive Care Unit were recruited in a tertiary grade A hospital in Wuxi from June 2020 to December 2021 and they were randomly assigned to the control group (n=49) or the observational group (n=50) by a random number table. Patients in the observational group received the clearance breathing while patients in the control group received routine care. Non-invasive ventilator treatment compliance, blood gas changes at different time periods, pulmonary function, tracheal intubation rate, average length of hospital stay, mMRC and CAT scores were compared between the two groups. Results: The treatment compliance, arterial pH, oxygenation index, and FEV1/FVC ratio of patients in the observational group were significantly higher than those in the control group (P<0.05). The mMRC, CAT score, average length of hospital stay and intubation rate were significantly lower than those in the control group (P<0.05). Conclusion: Clearance breathing for patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease undergoing first non-invasive ventilation can effectively improve the pulmonary function, improve the treatment compliance, and increase the success rate of ventilation. The clearance breathing is worth of promotion in clinical settings.

Key words: clearance breathing; beat; Acute Exacerbation of Chronic Obstructive Pulmonary Disease; first non-invasive ventilation; pulmonary function; compliance