Abstract: In order to clarify the definition of Evidence-Based Practice and understand the latest progress of existing Evidence-Based Nursing models, and to promote Evidence-Based Nursing practice more scientifically and effectively, this paper introduced and compared the four Evidence-Based Nursing models, namely i-PARIHS framework, ARCC model, JBI model and Johns Hopkins model, which concerned with the essence of Evidence-Based Practice. We explained the connotations and characteristics of the application of each model and provided a reference for the clinical health care personnel to select an appropriate evidence-based model to guide their Evidence-Based Practice.