Abstract: Objective: To develop family Caregiver Burden Scale for cancer patients (CBS-CP) according to Chinese culture background. Methods: We evaluated its reliability and validity based on the pre-survey results of developing CBS-CP. Results: The Content Validity Index (S-CVI) of CBS-CP scale was 0.936. The Exploratory Factor Analysis (EFA) results showed that the 5 factor model was consistent with the five-dimension design in conceptual framework of caregiver burden. The Cronbach's α and the test-retest reliability of the total scale and the five factors of CBS-CP were all greater than 0.7. Conclusion: The findings showed that both the reliability and validity of the CBS-CP were good. It was also proposed that future studies are needed to evaluate the reliability and validity of the CBS-CP based on large sample of the formal investigation.